Dear all, My co-authors and I are pleased to announce and share our recent paper titled *The Odontocete Ear Canal-Associated Lymphoid Tissue (ECALT) and Lymph Nodes: Morphological and Pathological Description with Immuno-Phenotypic Characterisation* De Vreese, S.; Centelleghe, C.; Graïc, J.-M.; Corrazola, G.; IJsseldijk, L.L.; André, M.; Mazzariol, S. The Odontocete Ear Canal-Associated Lymphoid Tissue (ECALT) and Lymph Nodes: Morphological and Pathological Description with Immuno-Phenotypic Characterisation. *Animals* *2022*, *12*, 2235. https://doi.org/10.3390/ani12172235 Simple Summary: The marine mammal immune system is of vital importance for the health of any marine mammal. With changes in the natural environment and with increasing anthropogenic stressors such as pollution, the immune system is challenged to unknown extents. Dolphins and other odontocete cetaceans have been shown to be particularly sensitive to anthropogenic influence in many aspects. In this regard, it is important to understand how these animals cope with novel stressors and how the immune system works and responds. In studying parallel issues related to underwater noise pollution, we looked at the cetacean ear canal and analysed in detail the cells of the immune system. Like the skin, it is likely to be exposed to the external environment and requires a local defence system as a first barrier to incoming threats. We studied the ear-canal associated immune system and describe the cell population using a variety of microscopic techniques. We describe healthy and activated tissue and cases with inflammation of the external ear canal and compare the different physiological states. As such, this study contributes to acquiring a general understanding of the odontocete cetacean immune system. Abstract: A changing marine environment with emerging natural and anthropogenic stressors challenges the marine mammal immune system. The skin and adnexa form a first protective barrier in the immune response, although this is still relatively understudied in cetaceans. The cellular and tissue morphology of the nodular and diffuse lymphoid tissue are not fully charted and the physiological responses are not yet completely understood. The odontocete’s external ear canal has a complex relationship with the external environment, with an artificial lumen rendering the inside of the canal a relatively secluded environment. In this work, we studied the odontocete ear canal-associated lymphoid tissue (ECALT) by histo- and immunohistochemistry (HC, IHC) with anti-CD3, anti-CD20, anti-Iba-1, anti-HLA-DR, and anti-vimentin antibodies. The ECALT cellular composition consists mainly of B-lymphocytes with the occasional presence of T-lymphocytes and the dispersed distribution of the macrophages. In cases of activation, the cellular reaction showed a similar pattern with the occasional presence of T-cells, plasma cells, and neutrophils. Nodular lymphoid tissue was generally in line with the description in other odontocetes, although with abundant erythrocytes throughout the entire organ. This study contributes to the understanding of the cellular composition of diffuse and nodular lymphoid tissue in several species of odontocetes, and in association with inflammation of the external ear canal. The paper can be accessed here: https://www.mdpi.com/2076-2615/12/17/2235 Best regards, Steffen De Vreese -- Steffen De Vreese, MVM, PhD Dipartimento di Biomedicina Comparata e Alimentazione (BCA) - Università degli Studi di Padova (It) Laboratori d'Aplicacions Bioacústiques (LAB) - Universitat Politécnica de Catalunya (Es) Linkedin.com/in/steffen-de-vreese-033a5994 Researchgate.net/profile/Steffen_De_Vreese