Dear readers, We are glad to announce the last article published by our laboratory (General Ecology at University of Zulia, Venezuela). Its title is: “Guiana Dolphin (*Sotalia guianensis*) in the Maracaibo Lake System, Venezuela: conservation, threats, and population overview.” This article was recently published in Frontiers in Marine Science (Open Access) as part of the research topic: Small cetaceans Conservation: Current Challenges and Opportunities. We found that high levels of Guiana dolphin mortality is related to fishing activities. However, there is a lack of standardized population assessments to compare abundance, population trends, distribution, and fisheries-related mortality of Guiana dolphins in the Maracaibo Lake System. We encouraged more research efforts to have a better perspective about all key-threat already identified in this aquatic system. Citation: Barrios-Garrido, H.; De Turris-Morales, K.; Espinoza-Rodríguez, N. 2021. Guiana Dolphin (*Sotalia guianensis*) in the Maracaibo Lake System, Venezuela: conservation, threats, and population overview. Frontiers in Marine Science, 594021. doi: https://doi.org/10.3389/fmars.2020.594021 Abstract The Guiana dolphin (*Sotalia guianensis*) home range is located across Central and South American countries, in coastal habitats in the Caribbean and Atlantic Ocean. Its distribution is scattered, with multiple population centers which are under threats that vary based on local realities. We compiled and assessed biological data from multiple sources (published and unpublished data) to improve our understanding regarding the Maracaibo Lake Management Unit, which is an isolated and unique population core of this species. We identified at least two distinguishable population centers throughout the Maracaibo Lake System, one in the northern portion—in the Gulf of Venezuela, and another in the southern portion of the Maracaibo Lake itself. Both centers have differences in some biological aspects (e.g., group size and habitat use), but similarities in the human-induced pressures (e.g., intentional take, habitat degradation, and traditional use). We detailed the uses of Guiana dolphin (consumptive and non-consumptive) by community members, including the use as talismans for indigenous fishers and consumption of its meat as a religious belief (Easter period), and dolphin watching tours carried out by local companies. In one artisanal port, at least 15 animals are intentionally taken annually to be used for local consumption, shark-bait, or trade; however, we acknowledge that this annual take is likely an underestimate. Further research is needed to clarify how and at what magnitude mentioned and other key-threats are impacting over Guiana dolphin MU in the Maracaibo Lake System. Keywords: intentional take, by-catch capture, ambient noise, heavy metals, management plan, aquatic bushmeat, small cetaceans, southern Caribbean. If you have questions or comments, please do not hesitate to contact us. Kind regards, On behalf of my co-authors, Dr. Hector Barrios-Garrido, author of correspondence