Summary: This paper details the Alabama Marine Mammal Stranding Network's response, from initial report to final disposition, for the first documented live sperm whale stranding in Alabama. The animal stranded out of habitat inside Mobile Bay. We highlight the challenges and successful aspects of the response, including multi-day live-animal monitoring, in-water sedation and euthanasia, transport, field necropsy, personnel safety, and the importance of interagency collaboration throughout the process. For the sedation and euthanasia phase of response, we provide detailed doses and times of drug delivery, animal response, and time to death. Our findings will benefit other stranding networks by informing best practices for coordinating large whale stranding response, particularly in areas where these strandings are rare and resources may be limited.